解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The corticospinal tract excitability is modulated when preparing movements. Earlier to movement execution, the excitability of the spinal cord increases waiting for supraspinal commands to release the movement. Movement execution and movement observation share processes within the motor system, although movement obser...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00353.2013
更新日期:2014-04-01 00:00:00
abstract::A question to be addressed in the present study is how different the eyes-closed (EC) and eyes-open (EO) resting states are across frequency bands in terms of efficiency and centrality of the brain functional network. We investigated both the global and nodal efficiency and betweenness centrality in the EC and EO rest...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00585.2013
更新日期:2014-04-01 00:00:00
abstract::Sexually dimorphic behaviors develop under the influence of sex steroids, which induce reversible changes in the underlying neural network of the brain. However, little is known about the proteins that mediate these activational effects of sex steroids. Here, we used a proteomics approach for large-scale identificatio...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00750.2013
更新日期:2014-04-01 00:00:00
abstract::Seminal work in animals indicates that learning a motor task results in long-term potentiation (LTP) in primary motor cortex (M1) and a subsequent occlusion of LTP induction (Rioult-Pedotti et al. J Neurophysiol 98: 3688-3695, 2007). Using various forms of noninvasive brain stimulation in conjunction with a motor lear...
journal_title:Journal of neurophysiology
pub_type: 评论,杂志文章
doi:10.1152/jn.00766.2013
更新日期:2014-03-01 00:00:00
abstract::Monitoring representative fractions of neurons from multiple brain circuits in behaving animals is necessary for understanding neuronal computation. Here, we describe a system that allows high-channel-count recordings from a small volume of neuronal tissue using a lightweight signal multiplexing headstage that permits...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00785.2013
更新日期:2014-03-01 00:00:00
abstract::Visual input provides vital information for helping us modify our walking pattern. For example, artificial optic flow can drive changes in step length during locomotion and may also be useful for augmenting locomotor training for individuals with gait asymmetries. Here we asked whether optic flow could modify the acqu...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00513.2013
更新日期:2014-03-01 00:00:00
abstract::Extracellular acidification induced by retinal horizontal cells has been hypothesized to underlie lateral feedback inhibition onto vertebrate photoreceptors. To test this hypothesis, the H(+)-sensitive fluorophore 5-hexadecanoylaminofluorescein (HAF) was used to measure changes in H(+) from horizontal cells isolated f...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00768.2013
更新日期:2014-03-01 00:00:00
abstract::Information about the position of an object that is held in both hands, such as a golf club or a tennis racquet, is transmitted to the human central nervous system from peripheral sensors in both left and right arms. How does the brain combine these two sources of information? Using a robot to move participant's passi...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00537.2013
更新日期:2014-03-01 00:00:00
abstract::Modularity in the central nervous system (CNS), i.e., the brain capability to generate a wide repertoire of movements by combining a small number of building blocks ("modules"), is thought to underlie the control of movement. Numerous studies reported evidence for such a modular organization by identifying invariant m...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00245.2013
更新日期:2014-02-01 00:00:00
abstract::PSD-95-like, disc-large (DLG) family membrane-associated guanylate kinase proteins (PSD/DLG-MAGUKs) are essential for regulating synaptic AMPA receptor (AMPAR) function and activity-dependent trafficking of AMPARs. Using a molecular replacement strategy to replace endogenous PSD-95 with SAP97β, we show that the protot...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00262.2013
更新日期:2014-02-01 00:00:00
abstract::Individuation refers to individuals' use of spatial and temporal properties to register an object as a distinct perceptual event relative to other stimuli. Although behavioral studies have examined both spatial and temporal individuation, neuroimaging investigations of individuation have been restricted to the spatial...
journal_title:Journal of neurophysiology
pub_type: 杂志文章,收录出版
doi:10.1152/jn.00534.2013
更新日期:2014-02-01 00:00:00
abstract::The inhibitory circuits of the striatum are known to be critical for motor function, yet their contributions to Parkinsonian motor deficits are not clear. Altered firing in the globus pallidus suggests that striatal medium spiny neurons (MSN) of the direct (D1 MSN) and indirect pathway (D2 MSN) are imbalanced during d...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00382.2013
更新日期:2014-02-01 00:00:00
abstract::Our group set out to develop a sensitive technique, capable of detecting output changes from the posterior fossa following a motor acquisition task. Transcranial magnetic stimulation (TMS) was applied over the right cerebellar cortex 5 ms in advance of test stimuli over the left cerebral motor cortex (M1), suppressing...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00661.2013
更新日期:2014-02-01 00:00:00
abstract::The primary motor cortex (MI) commands motor output after kinematics are planned from goals, thought to occur in a larger premotor network. However, there is a growing body of evidence that MI is involved in processes beyond action generation, and neuronal subpopulations may perform computations related to cue-to-acti...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00274.2013
更新日期:2014-01-01 00:00:00
abstract::Inactivation permits direct assessment of the functional contribution of a given brain area to behavior. Previous inactivation studies of the frontal eye field (FEF) have either used large permanent ablations or reversible pharmacological techniques that only inactivate a small volume of tissue. Here we evaluated the ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00398.2013
更新日期:2014-01-01 00:00:00
abstract::How does the motor system choose the speed for any given movement? Many current models assume a process that finds the optimal balance between the costs of moving fast and the rewards of achieving the goal. Here, we show that such models also need to take into account a prior representation of preferred movement speed...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00522.2013
更新日期:2014-01-01 00:00:00
abstract::Reach-to-grasp movements require information about the distance and size of target objects. Calibration of this information could be achieved via feedback information (visual and/or haptic) regarding terminal accuracy when target objects are grasped. A number of reports suggest that the nervous system alters reach-to-...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00112.2013
更新日期:2013-12-01 00:00:00
abstract::Feedback and descending projections from higher to lower brain centers play a prominent role in all vertebrate sensory systems. Feedback might be optimized for the specific sensory processing tasks in their target brain centers, but it has been difficult to connect the properties of feedback synapses to sensory tasks....
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00506.2013
更新日期:2013-12-01 00:00:00
abstract::Nervous systems are thought to encode information as patterns of electrical activity distributed sparsely through networks of neurons. These networks then process information by transforming one pattern of electrical activity into another. To store information as a pattern, a neural network must strengthen synapses be...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00533.2013
更新日期:2013-12-01 00:00:00
abstract::Contrasting theories of visual attention have emphasized selection by spatial location, individual features, and whole objects. We used functional magnetic resonance imaging to ask whether and how attention to one feature of an object spreads to other features of the same object. Subjects viewed two spatially superimp...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00828.2012
更新日期:2013-11-01 00:00:00
abstract::We examined the influence of focal cerebellar lesions on working memory (n-back task), gait, and the interaction between working memory and different gait tasks in a dual-task paradigm. The analysis included 17 young patients with chronic focal lesions after cerebellar tumor resection and 17 age-matched controls. Pati...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00062.2013
更新日期:2013-11-01 00:00:00
abstract::We often look at and sometimes reach for visible targets. Looking at a target is fast and relatively easy. By comparison, reaching for an object is slower and is associated with a larger cost. We hypothesized that, as a result of these differences, abrupt visual onsets may drive the circuits involved in saccade planni...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00968.2012
更新日期:2013-11-01 00:00:00
abstract::Processing of temporal information is key in auditory processing. In this study, we recorded single-unit activity from rat auditory cortex while they performed an interval-discrimination task. The animals had to decide whether two auditory stimuli were separated by either 150 or 300 ms and nose-poke to the left or to ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00381.2013
更新日期:2013-11-01 00:00:00
abstract::Local computation in microcircuits is an essential feature of distributed information processing in vertebrate and invertebrate brains. The insect antennal lobe represents a spatially confined local network that processes high-dimensional and redundant peripheral input to compute an efficient odor code. Social insects...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00260.2013
更新日期:2013-11-01 00:00:00
abstract::We characterized the electroresponsive and morphological properties of neurons in the bed nucleus of the stria terminalis (BNST). Previously, Rainnie and colleagues distinguished three cell types in the anterolateral region of BNST (BNST-AL): low-threshold bursting cells (LTB; type II) and regular spiking neurons that...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00408.2013
更新日期:2013-11-01 00:00:00
abstract::Humans and animals value the opportunity to choose by preferring alternatives that offer more rather than fewer choices. This preference for choice may arise not only from an increased probability of obtaining preferred outcomes but also from the freedom it provides. We used human neuroimaging to investigate the neura...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01057.2012
更新日期:2013-10-01 00:00:00
abstract::N-methyl-d-aspartate receptors (NMDARs) have been linked to schizophrenia because agents that bind the receptor, like ketamine and phencyclidine, are capable of inducing schizophrenia-like symptoms. Here we show that the amino acid homocysteine (HCY), which is increased in the blood of schizophrenia patients, reduces ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00809.2012
更新日期:2013-10-01 00:00:00
abstract::Olfactory bulb (OB) glomeruli, the initial sites of synaptic processing of odor information, exhibit high levels of nicotinic acetylcholine receptor (nAChR) expression and receive strong cholinergic input from the basal forebrain. The role of glomerular nAChRs in olfactory processing, however, remains to be elucidated...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00865.2012
更新日期:2013-10-01 00:00:00
abstract::Human functional magnetic resonance imaging (fMRI) studies, as well as lesion, drug, and single-cell recording studies in animals, suggest that the striatum plays a key role in associating sensory events with rewarding actions, both by facilitating reward processing and prediction (i.e., reinforcement learning) and by...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00164.2012
更新日期:2013-10-01 00:00:00
abstract::Rectification of surface EMG before spectral analysis is a well-established preprocessing method used in the detection of motor unit firing patterns. A number of recent studies have called into question the need for rectification before spectral analysis, pointing out that there is no supporting experimental evidence ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00296.2013
更新日期:2013-10-01 00:00:00
abstract::In humans, functional magnetic resonance imaging (fMRI) activity in the anterior cingulate cortex (ACC) and the nucleus accumbens (NAc) appears to reflect affective and motivational aspects of pain. The responses of this reward-aversion circuit to relief of pain, however, have not been investigated in detail. Moreover...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00284.2013
更新日期:2013-09-01 00:00:00
abstract::We have previously shown that the Coriolis torques that result when an arm movement is performed during torso rotation do not affect movement trajectory. Our purpose in the present study was to examine whether torso motion-induced Coriolis and other interaction torques are counteracted during a turn and reach (T&R) mo...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00104.2012
更新日期:2013-09-01 00:00:00
abstract::Optogenetics combines optics and genetics to control neuronal activity with cell-type specificity and millisecond temporal precision. Its use in model organisms such as rodents, Drosophila, and Caenorhabditis elegans is now well-established. However, application of this technology in nonhuman primates (NHPs) has been ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00153.2013
更新日期:2013-09-01 00:00:00
abstract::While the cochlear implant has successfully restored hearing to many deaf patients, it cannot benefit those without a functional auditory nerve or an implantable cochlea. As an alternative, the auditory midbrain implant (AMI) has been developed and implanted into deaf patients. Consisting of a single-shank array, the ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00022.2013
更新日期:2013-08-01 00:00:00
abstract::Abductor hallucis is the largest muscle in the arch of the human foot and comprises few motor units relative to its physiological cross-sectional area. It has been described as a postural muscle, aiding in the stabilization of the longitudinal arch during stance and gait. The purpose of this study was to describe the ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00944.2012
更新日期:2013-08-01 00:00:00
abstract::The generation of a behaviorally relevant cue to the speed of objects around us is critical to our ability to navigate safely within our environment. However, our perception of speed is often distorted by prevailing conditions. For instance, as luminance is reduced, our perception of the speed of fast-moving patterns ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00359.2012
更新日期:2013-08-01 00:00:00
abstract::Cardiovascular function is regulated by a dynamic balance composed of sympathetic and parasympathetic activity. Sympathoexcitatory presympathetic neurons (PSNs) in the rostral ventrolateral medulla project directly to cardiac and vasomotor sympathetic preganglionic neurons in the spinal cord. In proximity to the PSNs ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01054.2012
更新日期:2013-08-01 00:00:00
abstract::Two-Photon Processor (TPP) is a versatile, ready-to-use, and freely available software package in MATLAB to process data from in vivo two-photon calcium imaging. TPP includes routines to search for cell bodies in full-frame (Search for Neural Cells Accelerated; SeNeCA) and line-scan acquisition, routines for calcium s...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00087.2013
更新日期:2013-07-01 00:00:00
abstract::Dopamine neurons of the ventral tegmental area (VTA) signal the occurrence of a reward-predicting conditioned stimulus (CS) with a subsecond duration increase in post-CS firing rate. Important theories about reward-prediction error and reward expectancy have been informed by the substantial number of studies that have...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00784.2012
更新日期:2013-07-01 00:00:00
abstract::Electrical stimulation has been delivered to the basal ganglia (BG) to treat intractable symptoms of a variety of clinical disorders. However, it is still unknown how such treatments improve behavioral symptoms. A difficulty of this problem is that artificial signals created by electrical stimulation interact with int...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00046.2013
更新日期:2013-07-01 00:00:00